• The Anti-tumor drug discovery protocols: From in vitro to in vivo

    Tumor Animal Models: Methods-Protocols


    Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results.
    Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the book describes correct study design as well as the handling and housing of animals. It then goes on to describe the animal models available for different cancer types, from natural cancer models in mice and dogs to humanized animals. An...

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  • The Stem cell protocols: From laboratory to applications

    Cancer stem cells: Isolation and Culture


    The past twenty years have seen a significant worldwide reduction in mortality from cancers, largely due to improved early detection methods and develop- ment of more effective therapies, including adjuvant therapies. However, more than fifty percent of tumors do not respond to these therapies and more than seventy percent of patients relapse after five years. These failures are largely due to cancer stem cells (CSCs), found in all...

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  • The Anti-tumor drug discovery protocols: From in vitro to in vivo

    Cell Cytotoxicity Assay


    In vitro toxicity testing is the scientific analysis of the effects of toxic chemical substances on cultured bacteria or mammalian cells. In vitro (literally 'in glass') testing methods are employed primarily to identify potentially hazardous chemicals and/or to confirm the lack of certain toxic properties in the early stages of the development of potentially useful new substances such as therapeutic drugs, agricultural chemicals and food additives.

    In vitro assays for xenobiotic toxicity are recently carefully...

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New Releases

Cover for Cell Cytotoxicity Assay: In vitro Assays Cell Cytotoxicity Assay: In vitro Assays
Matthie Robert, Phuc Van Pham
April 16, 2016


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